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Publications

  1. Chen JC, Hoey DA, Chua M, Bellon R, Jacobs CR. Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism. FASEB J. 2016 Apr;30(4):1504-11. PMID: 26675708
  2. Nguyen AM, Young YN, Jacobs CR. The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling. Biol Open. 2015 Nov 24;4(12):1733-8. PMID: 26603473
  3. Lee KL, Guevarra MD, Nguyen AM, Chua MC, Wang Y, Jacobs CR. The primary cilium functions as a mechanical and calcium signaling nexus. Cilia. 2015 May 29;4:7. PMID: 26029358
  4. Duffy MP, Jacobs CR. Seeing the unseen: cell strain and mechanosensing. Biophys J. 2015 Apr 7;108(7):1583-4. PMID: 25863048
  5. Chen JC, Chua M, Bellon RB, Jacobs CR. Epigenetic changes during mechanically induced osteogenic lineage commitment. J Biomech Eng. 2015 Feb 1;137(2):020902. PMID: 25581684
  6. Espinha LC, Hoey DA, Fernandes PR, Rodrigues HC, Jacobs CR. Oscillatory fluid flow influences primary cilia and microtubule mechanics. Cytoskeleton (Hoboken). 2014 Jul;71(7):435-45. PMID: 25044764
  7. Lee KL, Hoey DA, Spasic M, Tang T, Hammond HK, Jacobs CR. Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo. FASEB J. 2014 Mar;28(3):1157-65. PMID: 24277577
  8. Downs ME, Nguyen AM, Herzog FA, Hoey DA, Jacobs CR. An experimental and computational analysis of primary cilia deflection under fluid flow. Comput Methods Biomech Biomed Engin. 2014;17(1):2-10. PMID: 22452422
  9. Leucht P, Temiyasathit S, Russell A, Arguello JF, Jacobs CR, Helms JA, Castillo AB. CXCR4 antagonism attenuates load-induced periosteal bone formation in mice. CXCR4 antagonism attenuates load-induced periosteal bone formation in mice. J Orthop Res. 2013 Nov;31(11):1828-38. PMID: 23881789
  10. Nguyen AM, Jacobs CR. Emerging role of primary cilia as mechanosensors in osteocytes. Bone. 2013 Jun;54(2):196-204. PMID: 23201223
  11. Leucht P, Monica SD, Temiyasathit S, Lenton K, Manu A, Longaker MT, Jacobs CR, Spilker RL, Guo H, Brunski JB, Helms JA. Primary cilia act as mechanosensors during bone healing around an implant. Med Eng Phys. 2013 Mar;35(3):392-402. PMID: 22784673
  12. Chen JC, Jacobs CR. Mechanically induced osteogenic lineage commitment of stem cells. Stem Cell Res Ther. 2013;4(5):107. PMID: 24004875
  13. Hoey DA, Tormey S, Ramcharan S, O'Brien FJ, Jacobs CR. Primary cilia-mediated mechanotransduction in human mesenchymal stem cells. Stem Cells. 2012 Nov;30(11):2561-70. PMID: 22969057
  14. Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C. Cellular and Molecular Bioengineering: A Tipping Point. Cell Mol Bioeng. 2012 Sep 1;5(3):239-253. PMID: 23264805
  15. Young YN, Downs M, Jacobs CR. Dynamics of the primary cilium in shear flow. Biophys J. 2012 Aug 22;103(4):629-39. PMID: 22947924
  16. Hoey DA, Chen JC, Jacobs CR. The primary cilium as a novel extracellular sensor in bone. Front Endocrinol (Lausanne). 2012 Jun 13;3:75. PMID: 22707948
  17. Hoey DA, Downs ME, Jacobs CR. The mechanics of the primary cilium: an intricate structure with complex function. J Biomech. 2012 Jan 3;45(1):17-26. PMID: 21899847
  18. Castillo AB, Blundo JT, Chen JC, Lee KL, Yereddi NR, Jang E, Kumar S, Tang WJ, Zarrin S, Kim JB, Jacobs CR. Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS One. 2012;7(9):e43291. PMID: 23028449
  19. Temiyasathit S, Tang WJ, Leucht P, Anderson CT, Monica SD, Castillo AB, Helms JA, Stearns T, Jacobs CR. Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading. PLoS One. 2012;7(3):e33368. PMID: 22428034
  20. Lee HG, Minematsu H, Kim KO, Celil Aydemir AB, Shin MJ, Nizami SA, Chung KJ, Hsu AC, Jacobs CR, Lee FY. Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials. 2011 Dec;32(35):9197-206. PMID: 21899882
  21. Hoey DA, Kelly DJ, Jacobs CR. A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun. 2011 Aug 19;412(1):182-7. PMID: 21810408
  22. Case N, Sen B, Thomas JA, Styner M, Xie Z, Jacobs CR, Rubin J. Steady and oscillatory fluid flows produce a similar osteogenic phenotype. Calcif Tissue Int. 2011 Mar;88(3):189-97. PMID: 21165611
  23. Arnsdorf EJ, Tummala P, Castillo AB, Zhang F, Jacobs CR. The epigenetic mechanism of mechanically induced osteogenic differentiation. J Biomech. 2010 Nov 16;43(15):2881-6. PMID: 20728889
  24. Tummala P, Arnsdorf EJ, Jacobs CR. The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment. Cell Mol Bioeng. 2010 Sep 1;3(3):207-212. PMID: 20823950
  25. Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics. Annu Rev Biomed Eng. 2010 Aug 15;12:369-400. PMID: 20617941
  26. Kwon RY, Temiyasathit S, Tummala P, Quah CC, Jacobs CR. Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. FASEB J. 2010 Aug;24(8):2859-68. PMID: 20371630
  27. Castillo AB, Jacobs CR. Mesenchymal stem cell mechanobiology. Curr Osteoporos Rep. 2010 Jun;8(2):98-104. PMID: 20425617]
  28. Wang L, Shi X, Zhao R, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption. Bone. 2010 May;46(5):1369-79. PMID: 19962460
  29. Litzenberger JB, Kim JB, Tummala P, Jacobs CR. Beta1 integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tissue Int. 2010 Apr;86(4):325-32. PMID:20213106
  30. Temiyasathit S, Jacobs CR. Osteocyte primary cilium and its role in bone mechanotransduction. Ann N Y Acad Sci. 2010 Mar;1192:422-8. PMID: 20392268
  31. Kelly DJ, Jacobs CR. The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells. Birth Defects Res C Embryo Today. 2010 Mar;90(1):75-85. PMID: 20301221
  32. Shivaram GM, Kim CH, Batra NN, Yang W, Harris SE, Jacobs CR. Novel early response genes in osteoblasts exposed to dynamic fluid flow. Philos Transact A Math Phys Eng Sci. 2010 Feb 13;368(1912):605-16. PMID: 20047941
  33. Kim CH, Kim KH, Jacobs CR. Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells. BMC Musculoskelet Disord. 2009 Sep 4;10:109. PMID: 19728893
  34. Arnsdorf EJ, Jones LM, Carter DR, Jacobs CR. The periosteum as a cellular source for functional tissue engineering. Tissue Eng Part A. 2009 Sep;15(9):2637-42. PMID:19207046
  35. Mishra A, Tummala P, King A, Lee B, Kraus M, Tse V, Jacobs CR. Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng Part C Methods. 2009 Sep;15(3):431-5. PMID: 19216642
  36. Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone. 2009 Aug;45(2):309-20. PMID: 19379851
  37. Folgado J, Fernandes PR, Jacobs CR, Pellegrini VD Jr. Influence of femoral stem geometry, material and extent of porous coating on bone ingrowth and atrophy in cementless total hip arthroplasty: an iterative finite element model. Comput Methods Biomech Biomed Engin. 2009 Apr;12(2):135-45. PMID: 19242833
  38. Arnsdorf EJ, Tummala P, Kwon RY, Jacobs CR. Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci. 2009 Feb 15;122(Pt 4):546-53. PMID: 19174467
  39. Arnsdorf EJ, Tummala P, Jacobs CR. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS One. 2009;4(4):e5388. PMID: 19401766
  40. Anderson CT, Castillo AB, Brugmann SA, Helms JA, Jacobs CR, Stearns T. Primary cilia: cellular sensors for the skeleton. Anat Rec (Hoboken). 2008 Sep;291(9):1074-8. PMID: 18727074
  41. Kwon RY, Lew AJ, and Jacobs CR. A microstructurally informed model for the mechanical response of three-dimensional actin networks. Comput Methods Biomech Biomed Engin. 2008 Aug;11(4):407-18. PMID: 18568835
  42. Sabsovich I, Clark JD, Liao G, Peltz G, Lindsey DP, Jacobs CR, Yao W, Guo TZ, and Kingery W. Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan. Bone. 2008 Feb;42(2):439-51. PMID: 17967568
  43. You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, and Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resportion due to mechanical loading. Bone. 2008 Jan;42(1):172-9. PMID: 17997378
  44. Godin LM, Suzuki S, Jacobs CR, Donahue HJ, and Donahue SW. Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction. Biomech Model Mechanobiol. 2007 Nov;6(6):391-8. PMID: 17082961
  45. Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, and Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13325-30. PMID: 17673554
  46. Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, and Jacobs CR. The role of actin cytoskeleton in oscillatory fluid-flow induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol. 2007 May;292(5):C1830-6. PMID: 17251324
  47. Kwon RY, and Jacobs CR. Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. J Biomech. 2007;40(14):3162-8. PMID: 17559856
  48. Malone AM, Anderson CT, Stearns T, Jacobs CR. Primary cilia in bone. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):301. PMID: 18094482
  49. Jacobs CR. Primary cilia. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):297-8. PMID: 18094479
  50. Kim CH, You L, Yellowley CE, Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 2006 Nov;39(5):1043-7. PMID: 16860618
  51. Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. 2006 Feb 15;367:1-16. PMID: 16361069
  52. Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. 2005 Sep;38(9):1909-17. PMID: 16023480
  53. Offley SC, Guo TZ, Wei T, Clark JD, Vogel H, Lindsey DP, Jacobs CR, Yao W, Lane NE, Kingery WS. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J Bone Miner Res. 2005 Feb;20(2):257-67. PMID: 15647820
  54. Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 2004 Nov;22(6):1283-9. PMID: 15475210
  55. Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, Yellowley CE. Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells. Bone. 2004 Sep;35(3):656-63. PMID: 15336601
  56. Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. The sensitivity of tibiofemoral contact pressure to the size and shape of the lateral and medial menisci. J Orthop Res. 2004 Jul;22(4):807-14. PMID: 15183438
  57. Guo TZ, Offley SC, Boyd EA, Jacobs CR, Kingery WS. Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I. Pain. 2004 Mar;108(1-2):95-107. PMID: 15109512
  58. Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Cycle number and waveform of fluid flow affect bovine articular chondrocytes. Biorheology. 2004;41(3-4):315-22. PMID: 15299264
  59. Kingery WS, Offley SC, Guo TZ, Davies MF, Clark JD, Jacobs CR. A substance P receptor (NK1) antagonist enhances the widespread osteoporotic effects of sciatic nerve section. Bone. 2003 Dec;33(6):927-36. PMID: 14678852
  60. Alford AI, Yellowley CE, Jacobs CR, Donahue HJ. Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytes. J Cell Biochem. 2003 Dec 1;90(5):938-44. PMID: 14624453
  61. Donahue TL, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J Biomech. 2003 Sep;36(9):1363-71. PMID: 12893045
  62. Alford AI, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism small star, filled. Bone. 2003 Jul;33(1):64-70. PMID: 12919700
  63. Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, Donahue HJ. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone. 2003 Apr;32(4):350-6. PMID: 12689677
  64. Saunders MM, Schwentker EP, Kay DB, Bennett G, Jacobs CR, Verstraete MC, Njus GO. Finite element analysis as a tool for parametric prosthetic foot design and evaluation. Technique development in the solid ankle cushioned heel (SACH) foot. Comput Methods Biomech Biomed Engin. 2003 Feb;6(1):75-87. PMID: 12623440
  65. Donahue TL, Rosenberg G, Jacobs CR, Weiss WJ. Finite element analysis of stresses developed in blood sacs of a pusherplate blood pump. Comput Methods Biomech Biomed Engin. 2003 Feb;6(1):7-15. PMID: 12623433
  66. Reilly GC, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology. 2003;40(6):591-603. PMID: 14610310
  67. Donahue SW, Donahue HJ, Jacobs CR. Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. J Biomech. 2003 Jan;36(1):35-43. PMID: 12485636
  68. Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint. J Biomech. 2003 Jan;36(1):19-34. PMID: 12485635
  69. You J, Jacobs CR, Steinberg TH, Donahue HJ. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem. 2002 Dec 13;277(50):48724-9. Epub 2002 Oct 9. PMID: 12376532
  70. Donahue TL, Hull ML, Rashid MM, Jacobs CR. A finite element model of the human knee joint for the study of tibio-femoral contact. J Biomech Eng. 2002 Jun;124(3):273-80. PMID: 12071261
  71. Saunders MM, You J, Trosko JE, Yamasaki H, Li Z, Donahue HJ, Jacobs CR. Gap junctions and fluid flow response in MC3T3-E1 cells. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1917-25. PMID: 11698250
  72. Donahue SW, Jacobs CR, Donahue HJ. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol. 2001 Nov;281(5):C1635-41. PMID: 11600427
  73. You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem. 2001 Apr 20;276(16):13365-71. Epub 2001 Jan 26. PMID: 11278573
  74. Kurokouchi K, Jacobs CR, Donahue HJ. Oscillating fluid flow inhibits TNF-alpha -induced NF-kappa B activation via an Ikappa B kinase pathway in osteoblast-like UMR106 cells. J Biol Chem. 2001 Apr 20;276(16):13499-504. Epub 2000 Nov 28. PMID: 11096064
  75. Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ. Aged bone displays an increased responsiveness to low-intensity resistance exercise. J Appl Physiol (1985). 2001 Apr;90(4):1359-64. PMID: 11247935
  76. Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates cytosolic calcium concentration in bovine articular chondrocytes. J Biomech. 2001 Jan;34(1):59-65. PMID: 11425081
  77. You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng. 2000 Aug;122(4):387-93. PMID: 11036562
  78. Lesh ML, Schneider DJ, Deol G, Davis B, Jacobs CR, Pellegrini VD Jr. The consequences of anterior femoral notching in total knee arthroplasty. A biomechanical study. J Bone Joint Surg Am. 2000 Aug;82-A(8):1096-101. PMID: 10954098
  79. Malecki EA, Buhl KM, Beard JL, Jacobs CR, Connor JR, Donahue HJ. Bone structural and mechanical properties are affected by hypotransferrinemia but not by iron deficiency in mice. J Bone Miner Res. 2000 Feb;15(2):271-7. PMID: 10703928
  80. Yellowley CE, Li Z, Zhou Z, Jacobs CR, Donahue HJ. Functional gap junctions between osteocytic and osteoblastic cells. J Bone Miner Res. 2000 Feb;15(2):209-17. PMID: 10703922
  81. Eckstein F, Merz B, Jacobs CR. Effects of joint incongruity on articular pressure distribution and subchondral bone remodeling. Adv Anat Embryol Cell Biol. 2000;152:iii-ix, 1-127. PMID: 10857219
  82. Black KP, Saunders MM, Stube KC, Moulton MJ, Jacobs CR. Effects of interference fit screw length on tibial tunnel fixation for anterior cruciate ligament reconstruction. Am J Sports Med. 2000 Nov-Dec;28(6):846-9. PMID: 11101107
  83. Jacobs CR, Yellowley CE, Nelson DV, Donahue HJ. Analysis of Time-Varying Biological Data Using Rainflow Cycle Counting. Comput Methods Biomech Biomed Engin. 2000;3(1):31-40. PMID: 11264837
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